2種類のトリガーモード

オプトジェネティクスでは光感受性タンパク質を脳の特定の神経細胞に遺伝子操作で発現させます。

一般に、興奮性タンパク質のチャネルロドプシン2などは高頻度の青色光パルスを使い、抑制性タンパク質のハロロドプシンなどは黄色光を継続的に照射します。

また、チャネルロドプシン2の改変型であるC128Sは青色光照射で興奮、黄色光照射で抑制ができます。

このそれぞれの実験系に対応できるよう、リモコンに3つのモード切替機能を加えました。

下図のように、P(Pulse)モードではトリガーパルス通りに発光し高頻度パルス刺激に向きます。

C(Continuous)モードではトリガーパルスごとに光のOn/Offが切り替わり、継続光照射に向きます。

2P(2チャンネルパルス)モードでは2チャンネル分の独立したトリガーパルスを使い、2色の刺激を独立してコントロールできます。型式に-2Pが付いた受信機はこのモードで使用します。2色で刺激するには2色LEDカニューラ、または脳表用2色LEDプローブを一緒に用いる必要があります。

※それぞれのモードに対応した受信機を使う必要があります。

型番に-PはPモード対応、-CはCモード対応です。


リモコン操作

リモコンはスティムレータからのトリガーシグナルを受け、受信機に信号を送信します。同期した光パルスがLEDカニューラの先端から出力されます。


2色刺激が可能

デュアルLEDカニューラで両側刺激が可能です。

オプトジェネティクスは光刺激で脳の特定の場所だけ興奮、あるいは抑制させて、動物の行動を操作できる夢の技術です。まるでテレビのリモコンのように、遠くからボタンでチャンネルを操作する…それを可能としたのが、北京脳科学センターの山中章弘教授とバイオリサーチセンターが共同開発した「テレオプト」なのです。

超小型・軽量の受信機でマウスにも対応。

LEDカニューラを変えるだけで光刺激の波長を変えられます。


超小型・軽量の受信機でマウスにも対応。

充電して繰り返し利用可能

受信機は充電して繰り返し使うことができます。


テレオプト基本セット

型式:Teleopto-set

  • テレオプトリモコン
  • テレオプト受信機
  • ※受信機を1つ要指定。指定なしで2g/パルス。
  • LEDカニューラ3個
  • ※色、長さ、ファイバー径を要指定。指定なしで青/10mm/φ250um
  • ※TeleLC(シングルLEDカニューラ)のみ
  • 赤外線投光器
  • テレオプトチャージャー
  • カニューラ埋め込みツール
  • ダミー受信機
  • 2ch BNCトリガーケーブル

仕様
通信方式 赤外線
通信距離

リモコン:1m、指向性あり 
投光器:3m、指向性あり

受信機

 
受信機 1g

約1.4g、待受け17時間

受信機 2g 約2.2g、待受け28時間
受信機 3g 約3.3g、待受け49時間

リモコン I/O

Trg端子

3-5Vトリガー入力、2ch
Pモード:Hi時On、Lo時Off
Cモード:立上り時On/Off切替

Ext端子 赤外線投光器拡張用
LEDカニューラ径 φ250、500、750um
電源

リモコンDC6V
受信機充電式/チャージャーDC5V


型式 品名
Teleopto-set テレオプト基本セット


論文

 

Identification of a novel perifornical-hypothalamic-areaprojecting serotonergic system that inhibits innate panic and conditioned fear responses

Cristian S. Bernabe, Izabela F. Caliman, Aline R. R. de Abreu, Andrei I. Molosh, William A. Truitt, Anantha Shekhar, Philip L. Johnson

Transl Psychiatry . 2024 Jan 25;14(1):60. doi: 10.1038/s41398-024-02769-3.

 

The delta opioid receptor agonist KNT-127 relieves innate anxiety-like behavior in mice by suppressing transmission from the prelimbic cortex to basolateral amygdala

Ayako Kawaminami, Daisuke Yamada, Toshinori Yoshioka, Azumi Hatakeyama, Moeno Nishida, Keita Kajino, Tsuyoshi Saitoh, Hiroshi Nagase, Akiyoshi Saitoh

Neuropsychopharmacol Rep . 2023 Dec 29. doi: 10.1002/npr2.12406.

 

Maternal separation early in life induces excessive activity of the central amygdala related to abnormal aggression

Ken-ichi Ohta, Chihiro Araki, Hidetoshi Ujihara, Keizo Iseki, Shingo Suzuki, Hikari Otabi, Haruki Kumei, Katsuhiko Warita, Takashi Kusaka, Takanori Miki

J Neurochem . 2023 Dec 1. doi: 10.1111/jnc.16020.

 

State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice

Takashi Nagashima, Kaori Mikami, Suguru Tohyama, Ayumu Konno, Hirokazu Hirai, Ayako M. Watabe

Front. Neural Circuits, 29 Nov 2023, Volume 17 https://doi.org/10.3389/fncir.2023.1273322

 

Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy

Hiroto Ito, Noriaki Fukatsu, Sheikh Mizanur Rahaman, Yasutaka Mukai, Shuntaro Izawa, Daisuke Ono, Thomas S Kilduff, Akihiro Yamanaka

Proc Natl Acad Sci U S A . 2023 Oct 10;120(41):e2301951120. doi: 10.1073/pnas.2301951120.

 

Optogenetic Stimulation of CA1 Pyramidal Neurons at Theta Enhances Recognition Memory in Brain Injured Animals

John I. Broussard, John B. Redell, Jing Zhao, Rebecca West, Ryota Homma, and Pramod K. Dash

J Neurotrauma . 2023 Aug 23. doi: 10.1089/neu.2023.0078.

 

Dissection of insular cortex layer 5 reveals two sublayers with opposing modulatory roles in appetitive drinking behavior

Makoto Takemoto, Shigeki Kato, Kazuto Kobayashi, Wen-Jie Song

iScience 2023 June 16 Volume 26, Issue 6, https://doi.org/10.1016/j.isci.2023.106985

 

Critical Role of Lateral Habenula Circuits in the Control of Stress-Induced Palatable Food Consumption

Chi Kin Ip, Jemma Rezitis, Lei Zhang, Yue Qi, Nikita Bajaj, Julia Koller, Aitak Farzi, Yan-Chuan Shi, Ramon Tasan, Herbert Herzog

Neuron . 2023 May 31;S0896-6273(23)00383-5. doi: 10.1016/j.neuron.2023.05.010.

 

Emotional association enhances perceptual memory through amygdalo-cortical inputs during NREM sleep

Yoshihito Saito, Yuma Osako, Maya Odagawa, Yasuhiro Oisi, Chie Matsubara, Shigeki Kato, Kazuto Kobayashi, Mitsuhiro Morita, Joshua P. Johansen, Masanori Murayama

bioRxiv 2023 May doi: https://doi.org/10.1101/2023.05.23.541852

 

Agrp-negative arcuate NPY neurons drive feeding under positive energy balance via altering leptin responsiveness in POMC neurons

Yue Qi, Nicola J Lee, Chi Kin Ip, Ronaldo Enriquez, Ramon Tasan, Lei Zhang, Herbert Herzog

Cell Metab . 2023 May 10;S1550-4131(23)00177-8. doi: 10.1016/j.cmet.2023.04.020.

 

Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice

Takashi Nagashima, Suguru Tohyama, Kaori Mikami, Masashi Nagase, Mieko Morishima, Atsushi Kasai, Hitoshi Hashimoto, Ayako M. Watabe

Nat Commun . 2022 Dec 30;13(1):7913. doi: 10.1038/s41467-022-35634-2

 

Hippocampus as a sorter and reverberatory integrator of sensory inputs

Masanori Nomoto, Emi Murayama, Shuntaro Ohno, Reiko Okubo-Suzuki, Shin-ichi Muramatsu, Kaoru Inokuchi

Nat Commun . 2022 Dec 20;13(1):7413. doi: 10.1038/s41467-022-35119-2.

 

Distinct roles of dopamine receptor subtypes in the nucleus accumbens during itch signal processing

Tong-Yu Liang, Hua Zhou, Yan-Gang Sun

J Neurosci . 2022 Oct 13;JN-RM-0821-22. doi: 10.1523/JNEUROSCI.0821-22.2022.

 

Glutamatergic neurons from the medial prefrontal cortex to the dorsal raphe nucleus regulate maternal aggression in lactating mice

Yoshikage Muroi, Toshiaki Ishii

Neurosci Res . 2022 Jul 8;S0168-0102(22)00190-0. doi: 10.1016/j.neures.2022.07.001.

 

A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease

Morgan Be´rard, Razan Sheta, Sarah Malvaut, Raquel Rodriguez-Aller, Maxime Teixeira, Walid Idi, Roxanne Turmel, Melanie Alpaugh, Marilyn Dubois, Manel Dahmene, Charleen Salesse, Je´roˆme LamontagneProulx, Marie-Kim St-Pierre, Omid Tavassoly , Wen Luo, Esther Del CidPellitero, Raza Qazi, Jae-Woong Jeong, Thomas M. Durcan, Luc Vallières, Marie-Eve Tremblay, Denis Soulet, Martin Le´vesque, Francesca Cicchetti, Edward A. Fon, Armen Saghatelyan, Abid Oueslati

PLoS Biol . 2022 Mar 9;20(3):e3001578. doi: 10.1371/journal.pbio.3001578. eCollection 2022 Mar

 

Dissection of insular cortex layer 5 reveals sublayers with opposing modulatory roles in appetitive behavior

Makoto Takemoto, Shigeki Kato, Kazuto Kobayashi, Wen-Jie Song

bioRxiv doi: https://doi.org/10.1101/2022.06.15.494020

 

Adolescent social isolation induces distinct changes in the medial and lateral OFC-BLA synapse and social and emotional alterations in adult mice

Hiroshi Kuniishi, Yuko Nakatake, Masayuki Sekiguchi, Mitsuhiko Yamada

Neuropsychopharmacology . 2022 Jun 13. doi: 10.1038/s41386-022-01358-6

 

Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses

Misaki Niu, Atsushi Kasai, Masato Tanuma, Kaoru Seiriki, Hisato Igarashi, Takahiro Kuwaki, Kazuki Nagayasu, Keita Miyaji, Hiroki Ueno, Wataru Tanabe, Kei Seo, Rei Yokoyama, Jin Ohkubo, Yukio Ago, Misuzu Hayashida, Ken-Ichi Inoue, Masahiko Takada, Shun Yamaguchi, Takanobu Nakazawa, Shuji Kaneko, Hiroyuki Okuno, Akihiro Yamanaka, Hitoshi Hashimoto

Sci Adv . 2022 Mar 18;8(11):eabi6375. doi: 10.1126/sciadv.abi6375

 

NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling

Yue Qi, Nicola J. Lee, Chi Kin Ip, Ronaldo Enriquez, Ramon Tasan, Lei Zhang, Herbert Herzog

Mol Metab . 2022 Feb 12;59:101455. doi: 10.1016/j.molmet.2022.101455

 

Optogenetic manipulations of CeA-CRF neurons modulate pain- and anxiety-like behaviors in neuropathic pain and control rats

Mariacristina Mazzitelli, Vadim Yakhnitsa, Benjamin Neugebauer, Volker Neugebauer

Neuropharmacology . 2022 Mar 15;210:109031. doi: 10.1016/j.neuropharm.2022.109031

 

Frontal-Sensory Cortical Projections Become Dispensable for Attentional Performance Upon a Reduction of Task Demand in Mice

Kevin J Norman, Julia Bateh, Priscilla Maccario, Christina Cho, Keaven Caro, Tadaaki Nishioka, Hiroyuki Koike, Hirofumi Morishita

Front Neurosci . 2022 Jan 11;15:775256. doi: 10.3389/fnins.2021.775256.

 

Role of Autism Risk Genes on Frontal-Thalamic Projections Underlying Social Processing in Mice

Brandon Stevens

Icahn School of Medicine at Mount Sinai ProQuest Dissertations Publishing,  2022. 29254523.

 

Ventral motor thalamic input to prelimbic cortex, but not to striatum, mediates cost-benefit decision-making in rats

Bianca Sieveritz, Shannon Hayashi Duke, Jeffery R. Wickens, Gordon W. Arbuthnott

bioRxiv doi: https://doi.org/10.1101/2022.02.11.48017

 

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Diana L Rodriguez-Munoz, Omar Jaidar, Marcela Palomero-Rivero, Mario A Arias-Garcia, Gordon W Arbuthnott, Violeta G Lopez-Huerta

J Vis Exp . 2021 Nov 22:(177). doi: 10.3791/63082.

 

Multiplexed representation of itch and mechanical and thermal sensation in the primary somatosensory cortex

Xiao-Jun Chen, Yan-He Liu, Ning-Long Xu, Yan-Gang Sun

J Neurosci . 2021 Oct 29;JN-RM-1445-21. doi: 10.1523/JNEUROSCI.1445-21.2021.

 

Optogenetic activation of DRN 5-HT neurons induced active wakefulness, not quiet wakefulness

Rika Moriya, Mitsuko Kanamaru, Naoki Okuma, Akira Yoshikawa, Kenji F Tanaka, Satoshi Hokari, Yasuyoshi Ohshima, Akihiro Yamanaka, Motoyasu Honma, Hiroshi Onimaru, Toshiaki Kikuchi, Masahiko Izumizaki

Brain Res Bull . 2021 Sep 24;177:129-142. doi: 10.1016/j.brainresbull.2021.09.019.

 

The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice

Mariko Ito, Masashi Nagase, Suguru Tohyama, Kaori Mikami, Fusao Kato, Ayako M. Watabe

Mol Brain . 2021 Jun 24;14(1):94. doi: 10.1186/s13041-021-00807-5.

 

Optogenetic Manipulations of Amygdala Neurons Modulate Spinal Nociceptive Processing and Behavior Under Normal Conditions and in an Arthritis Pain Model

Mariacristina Mazzitelli, Kendall Marshall, Andrew Pham, Guangchen, Volker Neugebauer

Front Pharmacol. (2021) May 25;12:668337. doi: 10.3389/fphar.2021.668337

 

Post-error recruitment of frontal sensory cortical projections promotes attention in mice

Kevin J. Norman, Justin S. Riceberg, Hiroyuki Koike, Julia Bateh, Sarah E. McCraney, Keaven Caro, Daisuke Kato, Ana Liang, Kazuhiko Yamamuro, Meghan E. Flanigan, Korey Kam, Elisa N. Falk, Daniel M. Brady, Christina Cho, Masato Sadahiro, Kohei Yoshitake, Priscilla Maccario, Michael P. Demars, Leah Waltrip, Andrew W. Varga, Scott J. Russo, Mark G. Baxter, Matthew L. Shapiro, Peter H. Rudebeck, Hirofumi Morishita

Neuron (2021) Feb doi: 10.1016/j.neuron.2021.02.001

 

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Striatal bilateral control of skilled forelimb movement

Violeta G Lopez-Huerta, Jai A Denton, Yoko Nakano, Omar Jaidar, Marianela Garcia-Munoz, Gordon W Arbuthnott

Cell Rep. (2021) Jan 19;34(3):108651. doi: 10.1016/j.celrep.2020.108651.

 

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Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors

Matthew Heina, Guangchen Ji, Dalton Tidwell, Preston D'Souza, Takaki Kiritoshi, Vadim Yakhnitsa, Edita Navratilova, Frank Porreca, Volker Neugebauer

Neuropharmacology (2021) Jan 12;185:108456. doi: 10.1016/j.neuropharm.2021.108456

 

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Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord

Takumi Oti, Keita Satoh, Daisuke Uta, Junta Nagafuchi, Sayaka Tateishi, Ryota Ueda, Keiko Takanami, Larry J Young, Antony Galione, John F Morris, Tatsuya Sakamoto, Hirotaka Sakamoto

Curr Biol. 2020 Oct 23;S0960-9822(20)31502-5. doi: 10.1016/j.cub.2020.09.089.

 

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Somatostatin neurons in the central amygdala mediate anxiety by disinhibition of the central sublenticular extended amygdala

Yajie Sun, Lei Qian, Li Xu, Sarah Hunt, Pankaj Sah

Molecular Psychiatry (2020) Oct 1; doi: 10.1038/s41380-020-00894-1

 

A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice

Kazuhiko Yamamuro, Lucy K. Bicks, Michael B. Leventhal, Daisuke Kato, Susanna Im, Meghan E. Flanigan, Yury Garkun, Kevin J. Norman, Keaven Caro, Masato Sadahiro, Klas Kullander, Schahram Akbarian, Scott J. Russo, Hirofumi Morishita

Nature Neuroscience (2020) Oct; 23(10): 1240-1252. doi: 10.1038/s41593-020-0695-6

 

Stress induces insertion of calcium-permeable AMPA receptors in the OFC-BLA synapse and modulates emotional behaviours in mice

Hiroshi Kuniishi, Daisuke Yamada, Keiji Wada, Mitsuhiko Yamada, Masayuki Sekiguchi

Translational Psychiatry 2020 May; 10(1) doi: 10.1038/s41398-020-0837-3

 

Using loss-and gain-of-function approaches to target amygdala-projecting serotonergic neurons in the dorsal raphe nucleus that enhance anxiety-related and conditioned fear behaviors

Cristian S Bernabe, Izabela F Caliman, William A Truitt, Andrei I Molosh, Christopher A Lowry, Anders Hay-Schmidt, Anantha Shekhar, Philip L Johnson

J Psychopharmacol. 2020 Apr;34(4):400-411. doi: 10.1177/0269881119900981. Epub 2020 Mar 10.


Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior

Lucy K. Bicks, Kazuhiko Yamamuro, Meghan E. Flanigan, Julia Minjung Kim, Daisuke Kato, Elizabeth K. Lucas, Hiroyuki Koike, Michelle S. Peng, Daniel M. Brady, Sandhya Chandrasekaran, Kevin J. Norman, Milo R. Smith, Roger L. Clem, Scott J. Russo, Schahram Akbarian, Hirofumi Morishita

Nature Communications 2020 Feb 21;11(1):1003. DOI: 10.1038/s41467-020-14740-z

 

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REM sleep-active MCH neurons are involved in forgetting hippocampus dependent memories

Shuntaro Izawa, Srikanta Chowdhury, Toh Miyazaki, Yasutaka Mukai, Daisuke Ono, Ryo Inoue, Yu Ohmura, Hiroyuki Mizoguchi, Kazuhiro Kimura, Mitsuhiro Yoshioka, Akira Terao, Thomas S. Kilduff, Akihiro Yamanaka

Science 2019 Sep; Vol.365, Issue 6459, pp. 1308-1313 DOI: 10.1126/science.aax9238

 

Correlative study using structural MRI and super-resolution microscopy to detect structural alterations induced by long-term optogenetic stimulation of striatal medium spiny neurons.

Yoshifumi Abe, Yuji Komaki, Fumiko Seki, Shinsuke Shibata, Hideyuki Okano, Kenji F. Tanaka

Neurochem Int. 2019 May; 125:163-174. DOI: 10.1016/j.neuint.2019.02.017.

 

Crucial role of feedback signals from prelimbic cortex to baolateral amygdala in the retrieval of morphine withdrawal memory.

Jiaojiao Song, Da Shao, Xinli Guo, Yanfang Zhao, Dongyang Cui, Qianqian Ma, Huan Sheng, Lan Ma, Bin Lai, Ming Chen, Ping Zheng

Science Advances 2019 Feb 20;5(2):eaat3210. DOI: 10.1126/sciadv.aat3210.

 

Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.Synchronized activation of striatal direct and indirect pathways underlies the behavior in unilateral dopamine-depleted mice.

Omar Jáidar, Luis Carrillo-Reid, Yuko Nakano, Violeta Gisselle Lopez-Huerta, Arturo Hernandez-Cruz, José Bargas, Marianela Garcia-Munoz, Gordon William Arbuthnott

Eur J Neurosci. 2019 Jan 11. DOI: 10.1111/ejn.14344

 

Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction.

Roger Marek, Li Xu, Robert K. P. Sullivan, Pankaj Sah

Nature Neuroscience (2018) 21(5):654-658. DOI: 10.1038

 

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Top-down cortical input during NREM sleep consolidates perceptual memory.

Miyamoto D, Hirai D, Fung CCA, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, Murayama M

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Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear.

Isosaka T, Matsuo T, Yamaguchi T, Funabiki K, Nakanishi S, Kobayakawa R, Kobayakawa K

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A Top-Down Cortical Circuit for Accurate Sensory Perception.

Manita S, Suzuki T, Homma C, Matsumoto T, Odagawara M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, Murayama M

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The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice.

Sato M, Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F

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